Hypoglycemic effects of bean (Phaseolus vulgaris L.) in rats with diabetes mellitus
DOI:
https://doi.org/10.17696/2318-3691.30.1.2023.169Keywords:
Diabetes Mellitus. Phaseolus. Hypoglycemia. Nutritional Sciences. Health Promotion. Metabolic Diseases.Abstract
Introduction: Beans are a legume with a high content of proteins, complex carbohydrates, minerals and vitamins. Epidemiological research points out that its continuous intake is associated with a large number of health improvements, among them the reduction in the risk of developing non-transmissible chronic diseases, such as diabetes mellitus (DM). Objective: To verify in the literature the hypoglycemic effect of beans in diabetic rodents. Methods: This is an integrative review carried out in the Science Direct, PubMed and Scopus databases using the descriptors “Phaseolus vulgaris” and “diabetes mellitus”. Original articles published between 2015 and 2020 in Portuguese, Spanish and English were included. Additionally, publications that did not present the proposed subject in the article abstract, review articles, research that did not use experimentation in rodents and duplicate publications were excluded. Results: The use of beans or preparations based on this food in diabetic rodents decreased glycaemia and glucose hemoglobin, triglycerides, cholesterol, low-density lipoproteins, levels of albumin and urea in the urine, and increased insulin in the blood and clearance of creatinine. In addition, elimination of ammonium groups, regulation of inflammation, oxidative response, cell signaling and apoptosis were observed. Conclusion: The studies presented show the effectiveness of the use of beans in reducing glycemic levels in diabetic rodents. It is noteworthy that more studies should be carried out to test its benefits in humans, since the use of this food would be an alternative method in the treatment of this pathology.
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